In Africa, an intermediate (savannah) cycle involves transmission of YF virus from tree hole–breeding Aedes spp. Virus is transmitted from monkeys to humans via mosquitoes when occupational or recreational activities encroach into the jungle. The sylvatic (jungle) cycle involves transmission of virus between nonhuman primates and mosquito species found in forest canopies. ![]() YF virus has 3 transmission cycles: sylvatic (jungle), intermediate (savannah), and urban. ![]() Nonhuman primates and humans are the main reservoirs of the virus, and anthroponotic (human-to-vector-to-human) transmission occurs. ![]() Vectorborne transmission of YF virus occurs via the bite of an infected mosquito, primarily Aedes or Haemagogus spp. Yellow fever (YF) virus is a single-stranded RNA virus that belongs to the genus Flavivirus. State health department or contact CDC’s Arboviral Diseases Branch (97 Infectious Agent
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